Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 3/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27582787 | 0.80 | PSEN1 (0.40) | ESR1ESR2LMNAMAPK1MEN1 | |
| SCHEMBL27582814 | 0.80 | AGTR1 (0.46) | ESR1ESR2LMNAMAPK1MEN1 | |
| SCHEMBL7012817 | 0.79 | MEN1 (0.34) | ESR1ESR2LMNAMAPK1MEN1 | |
| SCHEMBL7098290 | 0.79 | PTGER4 (0.48) | PTGER4MAPK1MEN1KMT2APSEN1 | |
| SCHEMBL1626336 | 0.77 | PTGER4 (0.49) | PTGER4ESR1ESR2LMNAMAPK1 | |
| SCHEMBL1624348 | 0.76 | PTGER4 (0.49) | PTGER4ESR1ESR2LMNAMAPK1 | |
| SCHEMBL3955596 | 0.75 | PTGER4 (0.46) | PTGER4ESR1ESR2LMNAMAPK1 | |
| SCHEMBL1625727 | 0.74 | PTGER4 (0.47) | PTGER4ESR1ESR2LMNAMAPK1 | |
| SCHEMBL1626626 | 0.74 | PTGER4 (0.47) | PTGER4ESR1ESR2LMNAMAPK1 | |
| SCHEMBL7019822 | 0.71 | EDNRB (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499305-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | Pfizer Japan Inc. (JP) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086371-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | PFIZER JAPAN INC. (JP) | 2003-10-23 | — | — | WO | disclosed |