Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27582780 | 0.84 | TSPO (0.37) | PTGER4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7016110 | 0.82 | — | — | |
| SCHEMBL27582837 | 0.81 | NR1H2 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6385097 | 0.81 | POLB (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7096928 | 0.81 | PSEN1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7097040 | 0.80 | ESR1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6426629 | 0.79 | PTGER4 (0.42) | PTGER4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27600241 | 0.78 | POLB (0.48) | MAPK1TSHRMEN1RAB9AKMT2A | |
| SCHEMBL7099008 | 0.78 | SMN1; SMN2 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28749912 | 0.77 | SMN1; SMN2 (0.42) | TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326606-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |