Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 8/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6414889 | 0.89 | HSD17B10 (0.41) | HSD17B10TSHRMAPTALDH1A1TDP1 | |
| SCHEMBL6422392 | 0.89 | — | — | |
| SCHEMBL5772185 | 0.84 | HIF1A (0.36) | TSHRMAPTALDH1A1TDP1GAA | |
| SCHEMBL2957517 | 0.83 | MAPT (0.43) | HSD17B10TSHRMAPTMEN1KMT2A | |
| SCHEMBL6409570 | 0.75 | MAOB (0.38) | HSD17B10TSHRMAPTALDH1A1GAA | |
| SCHEMBL6425261 | 0.75 | ALDH1A1 (0.52) | TSHRMAPTALDH1A1TDP1DPP4 | |
| SCHEMBL6424057 | 0.75 | DPP4 (0.39) | TSHRALDH1A1DPP4 | |
| SCHEMBL6423053 | 0.74 | ALDH1A1 (0.38) | TSHRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6424223 | 0.74 | MEN1 (0.41) | TSHRMAPTALDH1A1TDP1MEN1 | |
| SCHEMBL5719564 | 0.73 | TSHR (0.38) | HSD17B10TSHRMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1557165-A1 | COMBINATION DRUG | Eisai Co., Ltd. (JP) | 2005-07-27 | — | — | EP | disclosed |