SCHEMBL6427157

SCHEMBL6427157

O=C(O)c1ccc(S(=O)(=O)O)o1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.54
CA1 P00915 2/20 0.45
CA2 P00918 1/20 0.45
ALDH1A1 P00352 4/20 0.42
HTT P42858 1/20 0.42
HPGD P15428 1/20 0.41
POLB P06746 3/20 0.40
ESR1 P03372 1/20 0.40
NR4A1 P22736 1/20 0.40
APEX1 P27695 1/20 0.40
RECQL P46063 1/20 0.40
DUSP3 P51452 1/20 0.40
PTPN5 P54829 1/20 0.40
PTPN11 Q06124 1/20 0.40
ESR2 Q92731 1/20 0.40
CTDSP1 Q9GZU7 1/20 0.40
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8051710 0.96 TDP1 (0.51) TDP1CA1CA2ALDH1A1HTT
SCHEMBL30511184 0.84 TDP1 (0.56) TDP1ALDH1A1HTTHPGDPOLB
SCHEMBL15013774 0.81 ALDH1A1 (0.62) TDP1CA1CA2ALDH1A1HTT
SCHEMBL7663551 0.81 ALDH1A1 (0.44) TDP1CA1CA2ALDH1A1HTT
SCHEMBL18547769 0.81 TDP1 (0.53) TDP1ALDH1A1HTTHPGDPOLB
SCHEMBL8988328 0.81 ALDH1A1 (0.41) TDP1CA1CA2ALDH1A1HTT
SCHEMBL568367 0.81 TDP1 (0.53) TDP1ALDH1A1HTTHPGDPOLB
SCHEMBL13826361 0.78 CA1 (0.46) TDP1CA1CA2ALDH1A1HTT
SCHEMBL24462029 0.78 TDP1 (0.50) TDP1ALDH1A1HTTHPGDPOLB
SCHEMBL24462107 0.78 TDP1 (0.50) TDP1ALDH1A1HTTHPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050026968-A1 Heterocyclic amides with anti-tuberculosis activity UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2005-02-03 US claimed
WO-2005007625-A2 HETEROCYCLIC AMIDES WITH ANTI-TUBERCULOSIS ACTIVITY THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2005-01-27 WO claimed
US-11796916-B2 Pattern formation methods and photoresist pattern overcoat compositions ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2023-10-24 US disclosed
US-11796916-B2 Pattern formation methods and photoresist pattern overcoat compositions ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2023-10-24 US disclosed
US-20210232047-A1 PATTERN FORMATION METHODS AND PHOTORESIST PATTERN OVERCOAT COMPOSITIONS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2021-07-29 US disclosed
US-11003074-B2 Pattern formation methods and photoresist pattern overcoat compositions ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2021-05-11 US disclosed
US-10684549-B2 Pattern-formation methods ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2020-06-16 US disclosed
US-20180188654-A1 PATTERN-FORMATION METHODS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2018-07-05 US disclosed
US-20180188654-A1 PATTERN-FORMATION METHODS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2018-07-05 US disclosed
US-9869933-B2 Pattern trimming methods ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2018-01-16 US disclosed
US-9869933-B2 Pattern trimming methods ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2018-01-16 US disclosed
US-20150185620-A1 PHOTORESIST PATTERN TRIMMING COMPOSITIONS AND METHODS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2015-07-02 US disclosed
US-20150185620-A1 PHOTORESIST PATTERN TRIMMING COMPOSITIONS AND METHODS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2015-07-02 US disclosed
US-20140187027-A1 ION IMPLANTATION METHODS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2014-07-03 US disclosed
US-20140187027-A1 ION IMPLANTATION METHODS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2014-07-03 US disclosed
US-20140186772-A1 PHOTORESIST PATTERN TRIMMING METHODS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2014-07-03 US disclosed
US-20140186772-A1 PHOTORESIST PATTERN TRIMMING METHODS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2014-07-03 US disclosed
US-20050222408-A1 Heterocyclic amides with anti-tuberculosis activity UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2005-10-06 US disclosed
US-20050026968-A1 Heterocyclic amides with anti-tuberculosis activity UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2005-02-03 US disclosed
WO-2005007625-A2 HETEROCYCLIC AMIDES WITH ANTI-TUBERCULOSIS ACTIVITY THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2005-01-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050222408-A1 Heterocyclic amides with anti-tuberculosis activity TST, KAT5, NDUFS5 TDP1 4560/4885CA1 4543/4885CA2 3851/4885
US-20050026968-A1 Heterocyclic amides with anti-tuberculosis activity TST, KAT5, HDAC5 TDP1 4394/4885CA1 4539/4885CA2 3768/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.