Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.64 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.64 |
| ▸ | JAK2 | O60674 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | DDIT3 | P35638 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | CTSV | O60911 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6427480 | 0.82 | MEN1 (0.75) | MEN1KMT2APAX8JAK2MAPT | |
| SCHEMBL1520209 | 0.82 | DDIT3 (0.78) | MEN1KMT2APAX8JAK2MAPT | |
| SCHEMBL5224758 | 0.81 | MEN1 (0.67) | MEN1KMT2AMAPTNR1H4LMNA | |
| SCHEMBL6429046 | 0.81 | JAK2 (0.74) | MEN1KMT2APAX8JAK2MAPT | |
| SCHEMBL22822855 | 0.80 | JAK2 (0.73) | MEN1KMT2APAX8JAK2MAPT | |
| SCHEMBL24291456 | 0.80 | LMNA (0.71) | MEN1KMT2APAX8JAK2MAPT | |
| SCHEMBL11550139 | 0.78 | NR1H4 (0.81) | MEN1KMT2AMAPTNR1H4LMNA | |
| SCHEMBL22804220 | 0.77 | JAK2 (0.73) | MEN1KMT2APAX8JAK2MAPT | |
| SCHEMBL22822561 | 0.77 | JAK2 (0.77) | MEN1KMT2APAX8JAK2MAPT | |
| SCHEMBL13219526 | 0.77 | JAK2 (1.00) | MEN1KMT2APAX8JAK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026968-A1 | Heterocyclic amides with anti-tuberculosis activity | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2005-02-03 | — | — | US | claimed |
| US-20050222408-A1 | Heterocyclic amides with anti-tuberculosis activity | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2005-10-06 | — | — | US | disclosed |
| US-20050026968-A1 | Heterocyclic amides with anti-tuberculosis activity | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222408-A1 | Heterocyclic amides with anti-tuberculosis activity | TST, KAT5, NDUFS5 | MEN1 4703/4885KMT2A 2545/4885PAX8 4025/4885 |
| US-20050026968-A1 | Heterocyclic amides with anti-tuberculosis activity | TST, KAT5, HDAC5 | MEN1 4749/4885KMT2A 2476/4885PAX8 4030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.