⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966155 | 0.81 | — | — | |
| SCHEMBL25457 | 0.76 | — | — | |
| SCHEMBL9465875 | 0.71 | LMNA (0.48) | — | |
| SCHEMBL3929 | 0.67 | — | — | |
| SCHEMBL3668694 | 0.67 | — | — | |
| SCHEMBL8954574 | 0.65 | — | — | |
| SCHEMBL6466831 | 0.65 | — | — | |
| SCHEMBL4809247 | 0.65 | — | — | |
| SCHEMBL1521337 | 0.65 | — | — | |
| SCHEMBL121010 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033343-B1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS AG (CH) | 2018-12-05 | — | — | EP | claimed |
| US-20170183348-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2017-06-29 | — | — | US | claimed |
| EP-3033343-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | Novartis AG (CH) | 2016-06-22 | — | — | EP | claimed |
| US-20160136150-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS AG (CH) | 2016-05-19 | — | — | US | claimed |
| US-9227969-B2 | Compounds and compositions as inhibitors of MEK | NOVARTIS AG (CH) | 2016-01-05 | — | — | US | claimed |
| WO-2015022662-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS AG (CH) | 2015-02-19 | — | — | WO | claimed |
| WO-2015022663-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS AG (CH) | 2015-02-19 | — | — | WO | claimed |
| US-20150051209-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS AG (CH) | 2015-02-19 | — | — | US | claimed |
| EP-3033343-B1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS AG (CH) | 2018-12-05 | — | — | EP | disclosed |
| US-10011599-B2 | Compounds and compositions as inhibitors of MEK | NOVARTIS AG (CH) | 2018-07-03 | — | — | US | disclosed |
| US-20170183348-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2017-06-29 | — | — | US | disclosed |
| US-9629836-B2 | Compounds and compositions as inhibitors of MEK | NOVARTIS AG (CH) | 2017-04-25 | — | — | US | disclosed |
| EP-3033343-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | Novartis AG (CH) | 2016-06-22 | — | — | EP | disclosed |
| US-20160136150-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS AG (CH) | 2016-05-19 | — | — | US | disclosed |
| US-9227969-B2 | Compounds and compositions as inhibitors of MEK | NOVARTIS AG (CH) | 2016-01-05 | — | — | US | disclosed |
| WO-2015022662-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS AG (CH) | 2015-02-19 | — | — | WO | disclosed |
| US-20150051209-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS AG (CH) | 2015-02-19 | — | — | US | disclosed |
| WO-2015022663-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS AG (CH) | 2015-02-19 | — | — | WO | disclosed |
| US-20050244441-A1 | Cosmetic compositions | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2005-11-03 | — | — | US | disclosed |
| US-4088779-A | HYPOTENSIVE, ANTIFERTILITY | CIBA-GEIGY CORPORATION (US) | 1978-05-09 | — | — | US | disclosed |