Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | HTR6 | P50406 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | HEXA | P06865 | 1/20 | 0.34 |
| ▸ | HEXB | P07686 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15018437 | 0.72 | HEXA (0.45) | HTR2AMEN1MAPTKMT2APIM1 | |
| SCHEMBL1822854 | 0.71 | BRD4 (0.41) | HTR2AMEN1MAPTTHRBHTT | |
| SCHEMBL1650918 | 0.69 | HTR2A (0.59) | HTR2AMEN1MAPTMAPK1KMT2A | |
| SCHEMBL13591489 | 0.66 | MAPT (0.47) | TDP1MEN1MAPTTHRBMAPK1 | |
| SCHEMBL15018068 | 0.66 | HEXA (0.41) | TDP1MEN1MAPTTHRBMAPK1 | |
| SCHEMBL13171882 | 0.65 | MEN1 (0.52) | TDP1MEN1MAPTTHRBMAPK1 | |
| SCHEMBL3765842 | 0.64 | LMNA (0.49) | MEN1MAPTTHRBMAPK1KMT2A | |
| SCHEMBL10448839 | 0.64 | MEN1 (0.54) | TDP1MEN1MAPTTHRBMAPK1 | |
| SCHEMBL4063836 | 0.63 | HEXA (0.71) | TDP1MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL15064785 | 0.63 | HTR2A (0.56) | HTR2AMAPK1HTTPIM1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558231-A2 | DOSAGE ESCALATION AND DIVIDED DAILY DOSE OF ANTI-DEPRESSANTS TO TREAT NEUROLOGICAL DISORDERS | Cypress Bioscience, Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004030633-A2 | DOSAGE ESCALATION AND DIVIDED DAILY DOSE OF ANTI-DEPRESSANTS TO TREAT NEUROLOGICAL DISORDERS | CYPRESS BIOSCIENCE, INC. (US) | 2004-04-15 | — | — | WO | disclosed |