SCHEMBL642910

SCHEMBL642910

CN(C)C(=O)c1ccc(F)cc1F

nearest known ligand 0.61

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.61
CES1 P23141 3/20 0.61
KMT2A Q03164 2/20 0.59
HTT P42858 1/20 0.51
ACKR3 P25106 1/20 0.47
NPC1 O15118 1/20 0.46
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43
ATM Q13315 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
PDK2 Q15119 2/20 0.41
PIK3C3 Q8NEB9 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8566777 0.84 CES2 (0.61) CES2CES1KMT2AHTTNPC1
SCHEMBL31270828 0.84 CES2 (0.61) CES2CES1KMT2AHTTNPC1
SCHEMBL2735675 0.82 PDK2 (0.46) CES2CES1KMT2AHTTL3MBTL1
SCHEMBL355779 0.82 PDK2 (0.47) CES2CES1KMT2ANPC1L3MBTL1
SCHEMBL15218738 0.82 CES2 (0.53) CES2CES1KMT2AHTTACKR3
SCHEMBL6710893 0.82 CES2 (0.53) CES2CES1KMT2AHTTACKR3
SCHEMBL21516873 0.81 MAP2K1 (0.52) CES2CES1KMT2AL3MBTL1
SCHEMBL646187 0.81 DGAT1 (0.59) CES2CES1KMT2ANPC1L3MBTL1
SCHEMBL356822 0.81 KMT2A (0.42) CES2CES1KMT2AL3MBTL1
SCHEMBL19454401 0.81 KMT2A (0.42) CES2CES1KMT2ANPC1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2750238-B1 NON-AQUEOUS ELECTROLYTE AND BATTERY DAIKIN IND LTD (JP) 2017-09-06 EP disclosed
US-9627714-B2 Non-aqueous electrolyte and battery DAIKIN INDUSTRIES, LTD. (JP) 2017-04-18 US disclosed
US-9627714-B2 Non-aqueous electrolyte and battery DAIKIN INDUSTRIES, LTD. (JP) 2017-04-18 US disclosed
US-9509016-B2 Battery and non-aqueous electrolyte DAIKIN INDUSTRIES, LTD. (JP) 2016-11-29 US disclosed
US-9509016-B2 Battery and non-aqueous electrolyte DAIKIN INDUSTRIES, LTD. (JP) 2016-11-29 US disclosed
US-9455474-B2 Electrolytic solution DAIKIN INDUSTRIES, LTD. (JP) 2016-09-27 US disclosed
US-9455474-B2 Electrolytic solution DAIKIN INDUSTRIES, LTD. (JP) 2016-09-27 US disclosed
US-9397368-B2 Non-aqueous electrolyte solution DAIKIN INDUSTRIES, LTD. (JP) 2016-07-19 US disclosed
US-9397368-B2 Non-aqueous electrolyte solution DAIKIN INDUSTRIES, LTD. (JP) 2016-07-19 US disclosed
US-20150004501-A1 NON-AQUEOUS ELECTROLYTE AND BATTERY DAIKIN INDUSTRIES, LTD. (JP) 2015-01-01 US disclosed
US-20130224606-A1 NON-AQUEOUS ELECTROLYTE SOLUTION DAIKIN INDUSTRIES, LTD. (JP) 2013-08-29 US disclosed
US-20130224606-A1 NON-AQUEOUS ELECTROLYTE SOLUTION DAIKIN INDUSTRIES, LTD. (JP) 2013-08-29 US disclosed
EP-2010520-B1 HETEROBICYCLIC AMIDES FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES PFIZER PROD INC (US) 2012-09-12 EP disclosed
EP-2463283-A1 Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases Pfizer Products Inc. (US) 2012-06-13 EP disclosed
US-8119624-B2 Fused phenyl amido heterocyclic compounds PFIZER INC. (US) 2012-02-21 US disclosed
US-20110039821-A1 Fused Phenyl Amido Heterocyclic Compounds PFIZER INC 2011-02-17 US disclosed
US-7842713-B2 Fused phenyl amido heterocyclic compounds PFIZER INC (US) 2010-11-30 US disclosed
EP-2010520-A1 FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES Pfizer Products Incorporated (US) 2009-01-07 EP disclosed
US-20080280875-A1 FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS PFIZER INC. 2008-11-13 US disclosed
WO-2007122482-A1 FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES PFIZER PRODUCTS INC. (US) 2007-11-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110039821-A1 Fused Phenyl Amido Heterocyclic Compounds GCK, GCKR, HK1 CES2 1354/4885CES1 614/4885KMT2A 1755/4885
US-20080280875-A1 FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS GCK, GCKR, HK1 CES2 1354/4885CES1 614/4885KMT2A 1755/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.