Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 18/20 | 0.54 |
| ▸ | RARB | P10826 | 10/20 | 0.54 |
| ▸ | RARG | P13631 | 9/20 | 0.54 |
| ▸ | RXRG | P48443 | 9/20 | 0.54 |
| ▸ | RXRB | P28702 | 8/20 | 0.54 |
| ▸ | RARA | P10276 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428636 | 0.87 | RARG (0.54) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL6260299 | 0.84 | RXRA (0.72) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL6260306 | 0.84 | RXRA (0.72) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL6516792 | 0.82 | RXRA (0.69) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL27582113 | 0.80 | RXRA (0.53) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL6429289 | 0.80 | RXRA (0.53) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL6427532 | 0.78 | RXRA (0.48) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL4586465 | 0.78 | RXRA (0.49) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL4586461 | 0.78 | RXRA (0.49) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL4022985 | 0.77 | RARG (0.70) | RXRARARBRARGRXRGRXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906057-B1 | Methods for modulating FXR receptor activity | ALLERGAN, INC. (US) | 2005-06-14 | — | — | US | disclosed |