Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429459 | 0.74 | CRHR1 (0.37) | CRHR1KCNH2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6798178 | 0.65 | SMN1; SMN2 (0.37) | CRHR1CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL7605923 | 0.64 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL6428630 | 0.63 | MAPT (0.36) | CRHR1KMT2AGAA | |
| SCHEMBL6510726 | 0.60 | SLC6A4 (0.35) | CRHR1CYP2D6CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5845617 | 0.60 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL3347417 | 0.59 | AR (0.48) | HCRTR1HCRTR2 | |
| SCHEMBL6799761 | 0.59 | CRHR1 (0.37) | CRHR1CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL6799676 | 0.59 | POLB (0.45) | CRHR1CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL8824523 | 0.58 | SCN8A (0.37) | KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |