Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | PKM | P14618 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MITF | O75030 | 2/20 | 0.57 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LSS | P48449 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429493 | 0.88 | ALDH1A1 (0.60) | POLBPKMTDP1ALDH1A1MITF | |
| SCHEMBL6427583 | 0.87 | POLB (0.74) | POLBPKMTDP1ALDH1A1TSHR | |
| SCHEMBL6429668 | 0.87 | TDP1 (0.59) | POLBPKMTDP1ALDH1A1MITF | |
| SCHEMBL6427163 | 0.86 | ALDH1A1 (0.62) | POLBPKMTDP1ALDH1A1ABCC1 | |
| SCHEMBL12443384 | 0.86 | ALDH1A1 (0.62) | POLBPKMTDP1ALDH1A1TSHR | |
| SCHEMBL6429133 | 0.85 | POLB (0.71) | POLBPKMTDP1ALDH1A1TSHR | |
| SCHEMBL6428095 | 0.85 | ALDH1A1 (0.61) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL31349231 | 0.83 | POLB (0.56) | POLBPKMTDP1ALDH1A1MAPT | |
| SCHEMBL31349252 | 0.83 | KCNJ1 (0.53) | POLBPKMTDP1ALDH1A1TSHR | |
| SCHEMBL6427441 | 0.82 | ALDH1A1 (0.55) | POLBPKMTDP1ALDH1A1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050222408-A1 | Heterocyclic amides with anti-tuberculosis activity | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222408-A1 | Heterocyclic amides with anti-tuberculosis activity | TST, KAT5, NDUFS5 | POLB 2506/4885PKM 3371/4885TDP1 4560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.