SCHEMBL6429495

SCHEMBL6429495

O=C(ONCc1ccccc1)C(=O)ONCc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.48
IDO1 P14902 1/20 0.48
GAA P10253 1/20 0.47
KMT2A Q03164 3/20 0.46
HPGD P15428 3/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C19 P33261 2/20 0.46
MEN1 O00255 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C9 P11712 1/20 0.46
TSHR P16473 1/20 0.46
ALDH1A1 P00352 3/20 0.44
EPHX1 P07099 1/20 0.44
LMNA P02545 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
ADH1B P00325 1/20 0.43
ADH1C P00326 1/20 0.43
ADH1A P07327 1/20 0.43
ADH7 P40394 1/20 0.43
ALOX12 P18054 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8533323 0.92 THRB (0.45) THRBIDO1GAAKMT2AHPGD
SCHEMBL11176841 0.87 THRB (0.48) THRBIDO1GAAKMT2AHPGD
SCHEMBL2542923 0.83 CYP1A2 (0.47) THRBIDO1GAAKMT2AHPGD
SCHEMBL21611670 0.83 STING1 (0.54) THRBIDO1GAAKMT2AMEN1
SCHEMBL3614552 0.83 ALDH1A1 (0.52) THRBIDO1GAAHPGDCYP2C9
SCHEMBL28633509 0.82 EPHX2 (0.42) GAAKMT2AHPGDCYP2C19MEN1
SCHEMBL11500809 0.82 ALDH1A1 (0.53) GAAKMT2AHPGDMEN1TSHR
SCHEMBL27343899 0.82 MAPT (0.49) THRBIDO1GAAKMT2AHPGD
SCHEMBL27419910 0.82 ALDH1A1 (0.53) KMT2AHPGDCYP2D6TSHRALDH1A1
SCHEMBL10445230 0.82 MAPT (0.49) THRBIDO1GAAKMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108135916-A Chiral specificity boron-containing compound and its application in treating cancer or amyloidosis 翰林科学股份有限公司 2018-06-08 CN disclosed
CN-1578663-B Histone deacetylase inhibitors METHYLGENE INC 2011-05-25 CN disclosed
CN-101851173-A Inhibitors of histone deacetylase METHYLGENE INC 2010-10-06 CN disclosed
CN-1997649-B Inhibitors of histone deacetylase METHYLGENE INC 2010-08-11 CN disclosed
CN-100540547-C Inhibitors of histone deacetylase METHYLGENE INC (CA) 2009-09-16 CN disclosed
CN-1997649-A Inhibitors of histone deacetylase METHYLGENE INC (CA) 2007-07-11 CN disclosed
CN-1723207-A Histone deacetylase inhibitors METHYLGENE INC (CA) 2006-01-18 CN disclosed
EP-1225175-B1 Intermediate for the synthesis of D-chiro-3-inosose and (+)-D-chiro-inositol VIRGINIA TECH INTELL PROP (US) 2005-03-30 EP disclosed
CN-1578663-A Histone deacetylase inhibitors METHYLGENE INC (CA) 2005-02-09 CN disclosed
EP-0663915-B1 SYNTHESES OF D-CHIRO-3-INOSOSE AND (+)-D-CHIRO-INOSITOL VIRGINIA TECH INTELL PROP (US) 2002-12-04 EP disclosed
US-5633412-A Syntheses of D-chiro-3-inosose and (+)-D-chiro inositol VIRGINIA TECH INTELLECTUAL PROPERTIES (US) 1997-05-27 US disclosed
US-5602287-A Syntheses of D-chiro-3-inosose and (+)-D-chiro inositol VIRGINIA TECH INTELLECTUAL PROPERTIES (US) 1997-02-11 US disclosed
US-5602263-A REDUCTION OF AN EPOXYDIOL WITH SAMARIUM DIIODIDE VIRGINIA TECH INTELLECTUAL PROPERTIES (US) 1997-02-11 US disclosed
US-5600014-A HYDROLYSIS OF AN EPOXYDIOL VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) 1997-02-04 US disclosed
US-5578738-A EPOXYDIOL INTERMEDIATES VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) 1996-11-26 US disclosed
US-5563281-A DRUG INTERMEDIATES VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) 1996-10-08 US disclosed
EP-0663915-A1 SYNTHESES OF D-CHIRO-3-INOSOSE AND (+)-D-CHIRO-INOSITOL VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) 1995-07-26 EP disclosed
WO-1994007897-A1 SYNTHESES OF D-CHIRO-3-INOSOSE AND (+)-D-CHIRO-INOSITOL VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) 1994-04-14 WO disclosed
CN-1005711-B Preparation method of phenoxypropanolamine compounds 弗·哈夫曼-拉罗彻公司 1989-11-08 CN disclosed
CN-85101280-A Benzene oxygen propanol amine compounds 1987-01-17 CN disclosed