Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428843 | 0.88 | NR1H2 (0.52) | NR1H2NR1H3SCN9AMEN1ALDH1A1 | |
| SCHEMBL6426743 | 0.86 | CMA1 (0.57) | CMA1NR1H2NR1H3KDM4ESCN9A | |
| SCHEMBL6427394 | 0.84 | NR1H2 (0.51) | NR1H2NR1H3NPBWR1CHRM5 | |
| SCHEMBL8331785 | 0.83 | CMA1 (0.70) | CMA1GSK3AGSK3BCASP3KDM4E | |
| SCHEMBL6426845 | 0.81 | MAPT (0.50) | NR1H2NR1H3CASP3ALDH1A1KMT2A | |
| SCHEMBL6427000 | 0.81 | NR1H2 (0.60) | NR1H2NR1H3RAD51KDM4ESCN9A | |
| SCHEMBL30320663 | 0.80 | NR1H2 (0.71) | CMA1NR1H2NR1H3GSK3AGSK3B | |
| SCHEMBL6428883 | 0.80 | NR1H2 (0.48) | NR1H2NR1H3RAD51KDM4EMEN1 | |
| SCHEMBL6426484 | 0.79 | APAF1 (0.52) | NR1H2NR1H3RAD51MEN1ALDH1A1 | |
| SCHEMBL6427927 | 0.76 | MAPT (0.52) | NR1H2NR1H3KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005024755-A2 | MEDICAMENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS OR DIABETES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2005-03-17 | — | — | WO | disclosed |