SCHEMBL6426845

SCHEMBL6426845

O=C1C(Cl)=C(c2ccc(Cl)cc2)C(=O)N1Cc1ccc(F)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.50
THRB P10828 1/20 0.50
HTT P42858 2/20 0.47
NR1H2 P55055 1/20 0.47
NR1H3 Q13133 1/20 0.47
ALDH1A1 P00352 1/20 0.47
CASP3 P42574 1/20 0.47
KMT2A Q03164 1/20 0.44
CYP1A2 P05177 2/20 0.43
CYP2C19 P33261 1/20 0.43
RGS4 P49798 1/20 0.42
RGS8 P57771 1/20 0.42
CES2 O00748 1/20 0.40
BCHE P06276 1/20 0.40
CES1 P23141 1/20 0.40
LMNA P02545 1/20 0.40
HPGD P15428 1/20 0.40
UBE2N P61088 1/20 0.40
ATM Q13315 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6428843 0.92 NR1H2 (0.52) MAPTNR1H2NR1H3ALDH1A1KMT2A
SCHEMBL6427000 0.85 NR1H2 (0.60) MAPTHTTNR1H2NR1H3ALDH1A1
SCHEMBL6428883 0.83 NR1H2 (0.48) MAPTHTTNR1H2NR1H3ALDH1A1
SCHEMBL6426786 0.83 MAPT (0.46) MAPTTHRBHTTNR1H2NR1H3
SCHEMBL6426484 0.82 APAF1 (0.52) MAPTNR1H2NR1H3ALDH1A1KMT2A
SCHEMBL6429547 0.81 CMA1 (0.54) MAPTNR1H2NR1H3ALDH1A1CASP3
SCHEMBL6427927 0.79 MAPT (0.52) MAPTHTTNR1H2NR1H3ALDH1A1
SCHEMBL6427394 0.79 NR1H2 (0.51) NR1H2NR1H3CES2BCHECES1
SCHEMBL7558814 0.78 CES2 (0.53) MAPTTHRBHTTNR1H2NR1H3
SCHEMBL5235803 0.78 CYP1A2 (0.51) MAPTTHRBHTTALDH1A1CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005024755-A2 MEDICAMENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS OR DIABETES DECIPHERA PHARMACEUTICALS, LLC. (US) 2005-03-17 WO disclosed