SCHEMBL6429699

SCHEMBL6429699

[CH2]C(C)(C)COC(=O)CCC

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.46
DGKA P23743 1/20 0.38
TSHR P16473 2/20 0.36
LMNA P02545 3/20 0.35
HSD17B10 Q99714 1/20 0.35
CES2 O00748 1/20 0.35
CES1 P23141 1/20 0.35
PAM P19021 2/20 0.34
HTR2C P28335 1/20 0.34
FFAR3 O14843 2/20 0.33
HDAC3 O15379 2/20 0.33
HDAC1 Q13547 2/20 0.33
HDAC2 Q92769 2/20 0.33
HDAC8 Q9BY41 2/20 0.33
CYP1A2 P05177 1/20 0.33
MAPT P10636 1/20 0.32
NLRP3 Q96P20 1/20 0.32
DNM1 Q05193 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10688843 0.87 ALDH1A1 (0.46) ALDH1A1DGKATSHRLMNAHSD17B10
SCHEMBL15387119 0.86 DGKA (0.57) ALDH1A1DGKATSHRLMNAPAM
SCHEMBL8863613 0.84 ALDH1A1 (0.48) ALDH1A1DGKATSHRLMNAHSD17B10
SCHEMBL15387137 0.84 DGKA (0.60) ALDH1A1DGKATSHRLMNAPAM
SCHEMBL15387118 0.84 DGKA (0.60) ALDH1A1DGKATSHRLMNAPAM
SCHEMBL15387204 0.84 DGKA (0.60) ALDH1A1DGKATSHRLMNAPAM
SCHEMBL10494100 0.84 DGKA (0.60) ALDH1A1DGKATSHRLMNAPAM
SCHEMBL15387211 0.84 DGKA (0.60) ALDH1A1DGKATSHRLMNAPAM
SCHEMBL14931746 0.84 DGKA (0.60) ALDH1A1DGKATSHRLMNAPAM
SCHEMBL525740 0.83 ALDH1A1 (0.46) ALDH1A1DGKATSHRLMNAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1578741-A1 AROMATIC COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS 4SC AG (DE) 2005-09-28 EP disclosed
WO-2004056797-A1 AROMATIC COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS 4SC AG (DE) 2004-07-08 WO disclosed
WO-2003006425-A9 NOVEL COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS 4SC AG (DE) 2004-02-26 WO disclosed