⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2888506 | 0.90 | — | — | |
| SCHEMBL17009535 | 0.84 | — | — | |
| SCHEMBL1963806 | 0.82 | — | — | |
| SCHEMBL4971443 | 0.77 | — | — | |
| SCHEMBL16987053 | 0.76 | NPC1 (0.35) | — | |
| SCHEMBL25004733 | 0.72 | — | — | |
| SCHEMBL992402 | 0.72 | — | — | |
| SCHEMBL597712 | 0.72 | — | — | |
| SCHEMBL14671534 | 0.72 | — | — | |
| SCHEMBL23730626 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 367 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114605283-B | Method for efficiently preparing montelukast sodium side chain intermediate | 江苏阿尔法集团盛基药业(宿迁)有限公司 | 2024-11-19 | — | — | CN | claimed |
| CN-114605282-B | Preparation method of Montelukast sodium side chain intermediate | 江苏阿尔法集团盛基药业(宿迁)有限公司 | 2024-10-08 | — | — | CN | claimed |
| CN-116332816-A | Method for preparing 1-mercaptomethyl cyclopropylacetic acid by one-step method | 江苏阿尔法药业股份有限公司 | 2023-06-27 | — | — | CN | claimed |
| CN-114835614-A | Preparation process of 1-mercaptomethylcyclopropyl acetic acid | 江苏阿尔法药业股份有限公司 | 2022-08-02 | — | — | CN | claimed |
| CN-114605282-A | Preparation method of montelukast sodium side chain intermediate | 宿迁盛基医药科技有限公司 | 2022-06-10 | — | — | CN | claimed |
| CN-114605283-A | Method for efficiently preparing montelukast sodium side chain intermediate | 宿迁盛基医药科技有限公司 | 2022-06-10 | — | — | CN | claimed |
| CN-113943231-A | Preparation method of 1-hydroxymethyl cyclopropyl acetonitrile | 能特科技有限公司 | 2022-01-18 | — | — | CN | claimed |
| CN-103058884-B | Method for synthesizing 1-hydroxymethyl cyclopropyl acetonitrile | WUHAN SAITHCHEM. CO., LIMITED (CN) | 2014-10-29 | — | — | CN | claimed |
| CN-102633683-B | Synthesis method of 1-hydroxymethyl cyclopropylacetonitrile | YANCHENG JINGHUA CHEMICAL CO LTD | 2014-05-21 | — | — | CN | claimed |
| CN-103058884-A | Method for synthesizing 1-hydroxymethyl cyclopropyl acetonitrile | WUHAN SAITHCHEM CO LTD | 2013-04-24 | — | — | CN | claimed |
| WO-2007088545-A2 | NOVEL PROCESS FOR PREPARING 1-(MERCAPTOMETHYL) CYCLOPROPANEACETIC ACID, A USEFUL INTERMEDIATE IN THE PREPARATION OF MONTELUKAST AND SALTS THEREOF | CHEMAGIS LTD. (IL) | 2007-08-09 | — | — | WO | claimed |
| CN-1318400-C | Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid | DELMAR CHEMICALS INC (CA) | 2007-05-30 | — | — | CN | claimed |
| EP-1474386-B1 | PROCESS FOR THE PREPARATION OF 1-(MERCAPTOMETHYL)-CYCLOPROPANEACETIC ACID | DELMAR CHEMICALS INC (CA) | 2006-12-27 | — | — | EP | claimed |
| CN-1628096-A | Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid | DELMAR CHEMICALS INC (CA) | 2005-06-15 | — | — | CN | claimed |
| EP-1474386-A1 | PROCESS FOR THE PREPARATION OF 1-(MERCAPTOMETHYL)-CYCLOPROPANEACETIC ACID | Delmar Chemicals Inc. (CA) | 2004-11-10 | — | — | EP | claimed |
| WO-2003066582-A1 | PROCESS FOR THE PREPARATION OF 1-(MERCAPTOMETHYL)-CYCLOPROPANEACETIC ACID | DELMAR CHEMICALS INC. (CA) | 2003-08-14 | — | — | WO | claimed |
| US-6512140-B1 | Cyclization, iminoesterification, hydrolysis, in situ oxidation, sulfiding, cleavage, and purification | DELMAR CHEMICALS INC. (CA) | 2003-01-28 | — | — | US | claimed |
| EP-0805808-A1 | PROCESS FOR THE PREPARATION OF 1-(THIOMETHYL)-CYCLOPROPANEACETIC ACID | Merck & Co., Inc. (US) | 1997-11-12 | — | — | EP | claimed |
| WO-1996022987-A1 | PROCESS FOR THE PREPARATION OF 1-(THIOMETHYL)-CYCLOPROPANEACETIC ACID | MERCK & CO., INC. (US) | 1996-08-01 | — | — | WO | claimed |
| US-5523477-A | REACTING 1,1-CYCLOPROPANEDIMETHANOL WITH DIALKYL SULFITE IN PRESENCE OF ACID OR BASE TO FORM CYCLIC SULFITE, REMOVING ALCOHOL REACTION BY-PRODUCT | MERCK & CO., INC. (US) | 1996-06-04 | — | — | US | claimed |