Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6797534 | 0.81 | PDE1B (0.36) | SCN9AHPGDSLRRK2PDE1BPDE1C | |
| SCHEMBL5844055 | 0.81 | PDE1B (0.36) | SCN9AHPGDSLRRK2PDE1BPDE1C | |
| SCHEMBL6792201 | 0.73 | HSP90AA1 (0.41) | PDE1BPDE1CKCNH2 | |
| SCHEMBL6429703 | 0.73 | PDGFRB (0.36) | HPGDSLRRK2PDCD1CD274PDE1B | |
| SCHEMBL6799142 | 0.72 | LRRK2 (0.36) | LRRK2PDE1B | |
| SCHEMBL6799139 | 0.72 | LRRK2 (0.36) | LRRK2PDE1B | |
| SCHEMBL6799775 | 0.72 | LRRK2 (0.38) | HPGDSLRRK2PDCD1CD274PDE1B | |
| SCHEMBL5845474 | 0.71 | HPGDS (0.38) | HPGDSPDE1BPDE1CKCNH2 | |
| SCHEMBL6428206 | 0.71 | SCN9A (0.35) | SCN9ASCN5A | |
| SCHEMBL6800033 | 0.70 | GRM5 (0.38) | HPGDSPDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |