Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 11/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436842 | 0.83 | CRHR1 (0.43) | CRHR1CYP3A4ALOX15 | |
| SCHEMBL7437676 | 0.79 | CRHR1 (0.45) | CRHR1CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL5843381 | 0.78 | CRHR1 (0.34) | CRHR1KDM4EALDH1A1 | |
| SCHEMBL7440000 | 0.76 | CRHR1 (0.36) | CRHR1CYP3A4ALOX15 | |
| SCHEMBL7437868 | 0.76 | CRHR1 (0.36) | CRHR1CYP3A4ALOX15 | |
| SCHEMBL5600404 | 0.73 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL5844782 | 0.72 | CRHR1 (0.30) | CRHR1 | |
| SCHEMBL6303472 | 0.71 | CRHR1 (0.46) | CRHR1CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL7429959 | 0.71 | CRHR1 (0.38) | CRHR1CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL8498539 | 0.70 | CRHR1 (0.54) | CRHR1CYP3A4KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149583-A2 | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues | Pfizer Products Inc. (US) | 2001-10-31 | — | — | EP | claimed |
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |