Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437676 | 0.92 | CRHR1 (0.45) | CRHR1CYP3A4ALOX15KDM4EALDH1A1 | |
| SCHEMBL7440000 | 0.85 | CRHR1 (0.36) | CRHR1CYP3A4ALOX15 | |
| SCHEMBL6053051 | 0.83 | CRHR1 (0.38) | CRHR1CYP3A4ALOX15KDM4EALDH1A1 | |
| SCHEMBL7429966 | 0.79 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL7436842 | 0.77 | CRHR1 (0.43) | CRHR1CYP3A4ALOX15 | |
| SCHEMBL5599570 | 0.77 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL7437868 | 0.76 | CRHR1 (0.36) | CRHR1CYP3A4ALOX15 | |
| SCHEMBL6303472 | 0.75 | CRHR1 (0.46) | CRHR1CYP3A4ALOX15KDM4EALDH1A1 | |
| SCHEMBL5600475 | 0.74 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL5600248 | 0.72 | CRHR1 (0.34) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149583-A2 | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues | Pfizer Products Inc. (US) | 2001-10-31 | — | — | EP | claimed |