Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5842960 | 0.90 | CRHR1 (0.38) | CRHR1MAPTTDP1KDM4EMAPK1 | |
| SCHEMBL5842886 | 0.90 | CRHR1 (0.42) | CRHR1MAPTTDP1KDM4EMAPK1 | |
| SCHEMBL6429923 | 0.80 | CRHR1 (0.33) | CRHR1MAPTTDP1KDM4EMAPK1 | |
| SCHEMBL5843244 | 0.79 | CRHR1 (0.42) | CRHR1MAPTTDP1KDM4EMAPK1 | |
| SCHEMBL5844565 | 0.79 | CRHR1 (0.39) | CRHR1MAPTTDP1KDM4EMAPK1 | |
| SCHEMBL5843332 | 0.78 | S1PR4 (0.44) | CRHR1MAPTTDP1S1PR4NPC1 | |
| SCHEMBL5844211 | 0.78 | CRHR1 (0.38) | CRHR1MAPTMAPK1S1PR4 | |
| SCHEMBL5845747 | 0.78 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL5844295 | 0.75 | CRHR1 (0.38) | CRHR1MAPTTDP1KDM4EMAPK1 | |
| SCHEMBL5845050 | 0.72 | CRHR1 (0.37) | CRHR1MAPTTDP1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |