Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429928 | 0.80 | CRHR1 (0.43) | CRHR1S1PR4MAPTKDM4EMAPK1 | |
| SCHEMBL5842960 | 0.71 | CRHR1 (0.38) | CRHR1MAPTKDM4EMAPK1TDP1 | |
| SCHEMBL5842886 | 0.70 | CRHR1 (0.42) | CRHR1MAPTKDM4EMAPK1TDP1 | |
| SCHEMBL27493434 | 0.62 | ALDH1A1 (0.48) | MAPTMAPK1TDP1SMN1; SMN2MEN1 | |
| SCHEMBL5158453 | 0.61 | ALDH1A1 (0.46) | CRHR1MEN1LMNAHPGDKMT2A | |
| SCHEMBL10262523 | 0.60 | ALDH1A1 (0.49) | MAPTMAPK1TDP1SMN1; SMN2MEN1 | |
| SCHEMBL19616709 | 0.60 | MAPT (0.43) | CRHR1MAPTKDM4ETDP1NPC1 | |
| SCHEMBL29493403 | 0.60 | MAPT (0.43) | CRHR1MAPTKDM4ETDP1NPC1 | |
| SCHEMBL8160442 | 0.59 | GRM7 (0.40) | CRHR1ALDH1A1PDE2A | |
| SCHEMBL29696199 | 0.59 | MAPT (0.44) | MAPTKDM4EMAPK1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |