Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 2/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430364 | 0.81 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL5844489 | 0.78 | CRHR1 (0.43) | PDE1BPDE1APDE1CCRHR1 | |
| SCHEMBL6428305 | 0.75 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL6429459 | 0.66 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL5844690 | 0.65 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6400645 | 0.64 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL6082899 | 0.61 | CRHR1 (0.39) | PDE1BPDE1APDE1CCRHR1 | |
| SCHEMBL5843223 | 0.61 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL6450221 | 0.61 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL5844294 | 0.60 | CRHR1 (0.46) | PDE1BCRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |