Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.61 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12716740 | 0.89 | PPARG (0.61) | PPARGAGTR1AGTR2ACHEABCC4 | |
| SCHEMBL12716746 | 0.88 | PPARG (0.60) | PPARGAGTR1AGTR2ABCC4ABCB11 | |
| SCHEMBL541 | 0.88 | AGTR1 (0.69) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL10589345 | 0.88 | PPARG (0.59) | PPARGAGTR1AGTR2ABCC4ABCB11 | |
| SCHEMBL29032842 | 0.87 | PPARG (0.58) | PPARGAGTR1AGTR2ABCC4ABCB11 | |
| Hydrochloric Acid SCHEMBL524 | 0.87 | PPARG (0.58) | PPARGAGTR1AGTR2ABCC4ABCB11 | |
| SCHEMBL1014 | 0.86 | GP6 (0.66) | PPARGAGTR1AGTR2 | |
| SCHEMBL688 | 0.85 | PPARG (0.56) | PPARGAGTR1AGTR2ABCC4ABCB11 | |
| SCHEMBL3460736 | 0.84 | AGTR1 (0.62) | PPARGAGTR1AGTR2ABCC4ABCB11 | |
| SCHEMBL9854260 | 0.84 | PPARG (0.63) | PPARGAGTR1AGTR2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733366-B1 | Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics | DU PONT (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0324377-B1 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | DU PONT (US) | 1997-04-16 | — | — | EP | disclosed |
| EP-0733366-A2 | Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5155118-A | Administering angiotensin inhibitor | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| US-5153197-A | Treatment of hypertension with angiotensin II blocking imidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| US-5138069-A | Treating hypertension and congestive heart failure | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-08-11 | — | — | US | disclosed |
| US-5128355-A | Hypotensive | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0324377-A2 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-19 | — | — | EP | disclosed |
| WO-1989006233-A1 | ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES AND COMBINATIONS THEREOF WITH DIURETICS AND NSAIDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-13 | — | — | WO | disclosed |