Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.74 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.66 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | INPP5D | Q92835 | 1/20 | 0.64 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.61 |
| ▸ | SHBG | P04278 | 1/20 | 0.61 |
| ▸ | PGR | P06401 | 1/20 | 0.61 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.61 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | AR | P10275 | 1/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | MGAM | O43451 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | CDC25A | P30304 | 2/20 | 0.58 |
| ▸ | POLA1 | P09884 | 1/20 | 0.58 |
| ▸ | FGF2 | P09038 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholestan-3-One SCHEMBL31415973 | 1.00 | GPBAR1 (0.74) | GPBAR1SRD5A1SRD5A2CYP2D6CYP2C19 | |
| Cholestan-3-One SCHEMBL14078297 | 1.00 | GPBAR1 (0.74) | GPBAR1SRD5A1SRD5A2CYP2D6CYP2C19 | |
| Cholestan-3-One SCHEMBL3034745 | 1.00 | GPBAR1 (0.74) | GPBAR1SRD5A1SRD5A2CYP2D6CYP2C19 | |
| Cholestan-3-One SCHEMBL17817037 | 1.00 | GPBAR1 (0.74) | GPBAR1SRD5A1SRD5A2CYP2D6CYP2C19 | |
| Cholestan-3-One SCHEMBL17817346 | 1.00 | GPBAR1 (0.74) | GPBAR1SRD5A1SRD5A2CYP2D6CYP2C19 | |
| Cholestan-3-One SCHEMBL14313461 | 1.00 | GPBAR1 (0.74) | GPBAR1SRD5A1SRD5A2CYP2D6CYP2C19 | |
| Cholestan-3-One SCHEMBL24151938 | 1.00 | GPBAR1 (0.74) | GPBAR1SRD5A1SRD5A2CYP2D6CYP2C19 | |
| Cholestan-3-One SCHEMBL14360529 | 1.00 | GPBAR1 (0.74) | GPBAR1SRD5A1SRD5A2CYP2D6CYP2C19 | |
| Cholestan-3-One SCHEMBL12273856 | 1.00 | GPBAR1 (0.74) | GPBAR1SRD5A1SRD5A2CYP2D6CYP2C19 | |
| Cholestan-3-One SCHEMBL30428888 | 1.00 | GPBAR1 (0.74) | GPBAR1SRD5A1SRD5A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 321 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260077000-A1 | METABOLIC MODULATION OF INTRATUMORAL CHOLESTEROL WITH ENGINEERED BACTERIA FOR THE TREATMENT OF CANCERS | UNIV HONG KONG BAPTIST UNIV (CN) | 2026-03-19 | — | — | US | claimed |
| WO-2024259158-A2 | LIPID NANOPARTICLES FOR PEPTIDE DELIVERY AND METHODS OF MAKING AND USING THE SAME | CORNELL UNIVERSITY (US) | 2024-12-19 | — | — | WO | claimed |
| US-12138285-B2 | Cholesterol reducing compositions and methods of use thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-11-12 | — | — | US | claimed |
| US-20240024381-A1 | CHOLESTEROL REDUCING COMPOSITIONS AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-01-25 | — | — | US | claimed |
| US-11633436-B2 | Cholesterol reducing compositions and methods of use thereof | THE BROAD INSTITUTE, INC. (US) | 2023-04-25 | — | — | US | claimed |
| US-20210128642-A1 | CHOLESTEROL REDUCING COMPOSITIONS AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-05-06 | — | — | US | claimed |
| EP-3781697-A1 | METHOD FOR DETERMINING CHEMICAL COMPOUNDS IN WASTE | Renescience A/S (DK) | 2021-02-24 | — | — | EP | claimed |
| WO-2019201765-A1 | METHOD FOR DETERMINING CHEMICAL COMPOUNDS IN WASTE | RENESCIENCE A/S (DK) | 2019-10-24 | — | — | WO | claimed |
| EP-2850430-A1 | ANALYSIS OF A PANEL OF CEREBROTENDINOUS XANTHOMATOSIS BIOMARKERS USING SITE SPECIFIC DERIVATION AND LC/MS/MS WORKFLOW | Dh Technologies Development Pte. Ltd. (SG) | 2015-03-25 | — | — | EP | claimed |
| EP-2747750-A2 | LIPOSOME COMPRISING AT LEAST A CHOLESTEROL DERIVATIVE | Trophos (FR) | 2014-07-02 | — | — | EP | claimed |
| EP-1601363-A2 | USE OF DERIVATIVES OF CHOLEST-4-EN-3-ONE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, NOVEL DERIVATIVES AND PREPARATION METHOD THEREOF | Trophos (FR) | 2005-12-07 | — | — | EP | claimed |
| WO-2004082581-A2 | USE OF DERIVATIVES OF CHOLEST-4-EN-3-ONE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, NOVEL DERIVATIVES AND PREPARATION METHOD THEREOF | TROPHOS (FR) | 2004-09-30 | — | — | WO | claimed |
| US-6312919-B1 | CONVERTING CHOLESTEROL TO 4-CHOLESTEN-3-ONE, THEN TO COPROSTAN-3-ONE, AND THEN TO COPROSTANOL BY VARIOUS DEHYDROGENASES ISOLATED FROM A EUBACTERIUM SPECIES; FOR REDUCED CHOLESTEROL FOODS AND FEEDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-11-06 | — | — | US | claimed |
| US-20010034041-A1 | Process for producing a cholesterol-reduced substance | SAITOH CHIAKI (JP) | 2001-10-25 | — | — | US | claimed |
| US-20010005587-A1 | Cholesterol dehydrogenase, coprostan-3-one dehydrogenase and 4-cholesten-3-one dehydrogenase, compositions containing the dehydrogenases, and method for reducing amount of cholesterol using the compositions | SAITOH CHIAKI (JP) | 2001-06-28 | — | — | US | claimed |
| EP-0879892-A1 | PROCESS FOR PREPARING CHOLESTEROL-LOWERING COMPOUND | Kyowa Hakko Co., Ltd. (JP) | 1998-11-25 | — | — | EP | claimed |
| EP-0465155-B1 | Non-linear optical material containing steroidal ketone compound | HITACHI CHEMICAL CO LTD (JP) | 1996-02-28 | — | — | EP | claimed |
| US-4438033-A | Steroidal chiral phosphines, methods for their preparation, catalytic systems containing them and catalytic processes in which they are used | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1984-03-20 | — | — | US | claimed |
| EP-0081149-A1 | New steroidal chiral phosphines, methods for their preparation, catalytic systems containing them and catalytic processes in which they are used | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1983-06-15 | — | — | EP | claimed |
| US-4020059-A | Process for preparing tertiary amines | NIPPON SHOKUBAI KAGAKU KOGYO CO., LTD. (JA) | 1977-04-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240024381-A1 | CHOLESTEROL REDUCING COMPOSITIONS AND METHODS OF USE THEREOF | CETP, DHCR7, HMGCR | GPBAR1 1197/4885SRD5A1 222/4885SRD5A2 269/4885 |
| US-11633436-B2 | Cholesterol reducing compositions and methods of use thereof | CETP, DHCR7, HMGCR | GPBAR1 1197/4885SRD5A1 222/4885SRD5A2 269/4885 |
| US-12138285-B2 | Cholesterol reducing compositions and methods of use thereof | CETP, DHCR7, HMGCR | GPBAR1 1197/4885SRD5A1 222/4885SRD5A2 269/4885 |
| US-20260077000-A1 | METABOLIC MODULATION OF INTRATUMORAL CHOLESTEROL WITH ENGINEERED BACTERIA FOR THE TREATMENT OF CANCERS | CYP4X1, CYP46A1, CYP11A1 | GPBAR1 473/4885SRD5A1 42/4885SRD5A2 41/4885 |
| US-20210128642-A1 | CHOLESTEROL REDUCING COMPOSITIONS AND METHODS OF USE THEREOF | CETP, DHCR7, HMGCR | GPBAR1 1197/4885SRD5A1 222/4885SRD5A2 269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.