SCHEMBL6430745

SCHEMBL6430745

CN(c1ccccn1)C1CNCC(Br)C1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 1/20 0.39
JAK3 P52333 1/20 0.39
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.34
SLC6A2 P23975 3/20 0.34
SLC6A4 P31645 3/20 0.34
SLC6A3 Q01959 3/20 0.34
LCK P06239 1/20 0.34
CHRM2 P08172 1/20 0.32
ADRA2A P08913 1/20 0.32
ADRA2B P18089 1/20 0.32
ADRA2C P18825 1/20 0.32
DRD1 P21728 1/20 0.32
HTR2A P28223 1/20 0.32
ADRA1A P35348 1/20 0.32
HRH1 P35367 1/20 0.32
OPRK1 P41145 1/20 0.32
KCNH2 Q12809 1/20 0.32
TRPM8 Q7Z2W7 4/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4522029 0.86 CYP2D6 (0.47) JAK2JAK3CYP2D6CYP2C19L3MBTL1
SCHEMBL2478228 0.74 LCK (0.48) JAK2JAK3CYP2D6CYP2C19L3MBTL1
SCHEMBL29591041 0.74 JAK3 (0.45) JAK2JAK3CYP2D6CYP2C19L3MBTL1
SCHEMBL1306110 0.74 JAK3 (0.45) JAK2JAK3CYP2D6CYP2C19L3MBTL1
SCHEMBL27863544 0.73 LCK (0.54) JAK2JAK3CYP2D6CYP2C19L3MBTL1
Hydrochloric Acid SCHEMBL4802990 0.73 LCK (0.47) JAK2JAK3CYP2D6CYP2C19L3MBTL1
Hydrochloric Acid SCHEMBL4133640 0.73 JAK3 (0.44) JAK2JAK3CYP2D6CYP2C19L3MBTL1
Hydrochloric Acid SCHEMBL21641049 0.72 TRPM8 (0.40) CYP2D6CYP2C19TRPM8CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL30585784 0.72 TRPM8 (0.40) CYP2D6CYP2C19TRPM8CHRNB4CHRNA3
SCHEMBL17961824 0.70 DRD2 (0.36) CYP2D6CYP2C19SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1608377-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING INHIBITORS OF FAB I AND FURTHER ANTIBIOTICS Affinium Pharmaceuticals, Inc. (CA) 2005-12-28 EP disclosed
EP-1575951-A1 HETEROCYCLIC COMPOUNDS, METHODS OF MAKING THEM AND THEIR USE IN THERAPY Affinium Pharmaceuticals, Inc. (CA) 2005-09-21 EP disclosed
WO-2004082586-A2 PHAMACEUTICAL COMPOSITIONS COMPRISING INHIBITORS OF FAB I AND FURTHER ANTIBIOTICS AFFINIUM PHARMACEUTICALS, INC. (US) 2004-09-30 WO disclosed
WO-2004052890-A1 HETEROCYCLIC COMPOUNDS, METHODS OF MAKING THEM AND THEIR USE IN THERAPY AFFINIUM PHARMACEUTICALS, INC. (CA) 2004-06-24 WO disclosed