Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 6/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 15/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | KIF5B | P33176 | 2/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6434691 | 0.89 | FLT1 (0.69) | FLT1FGFR1KDRPDGFRBRET | |
| SCHEMBL6436364 | 0.86 | FLT1 (0.50) | FLT1FGFR1KDRPDGFRBRET | |
| SCHEMBL6431137 | 0.86 | EHMT2 (0.45) | FLT1FGFR1KDRPDGFRBRET | |
| SCHEMBL6431484 | 0.84 | KDR (0.41) | FLT1FGFR1KDRRETKIF5B | |
| SCHEMBL6436584 | 0.84 | RET (0.46) | FLT1FGFR1KDRPDGFRBRET | |
| SCHEMBL6433338 | 0.82 | FLT1 (0.67) | FLT1FGFR1KDRFGFR2FGFR4 | |
| SCHEMBL6430841 | 0.81 | FLT1 (0.80) | FLT1FGFR1KDRRETKIF5B | |
| Hydrochloric Acid SCHEMBL6431075 | 0.80 | FLT1 (0.79) | FLT1FGFR1KDRRETKIF5B | |
| SCHEMBL6431742 | 0.76 | FLT1 (0.61) | FLT1FGFR1KDRPDGFRBRET | |
| SCHEMBL6431154 | 0.76 | FLT1 (0.52) | FLT1FGFR1KDRRETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | claimed |