Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 14/20 | 0.67 |
| ▸ | KDR | P35968 | 13/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.67 |
| ▸ | FLT4 | P35916 | 5/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | GAK | O14976 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.42 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6434261 | 0.91 | FLT1 (0.56) | FLT1KDRFGFR1FLT4EGFR | |
| SCHEMBL6431608 | 0.90 | FLT1 (0.55) | FLT1KDRFGFR1FLT4EGFR | |
| SCHEMBL6437938 | 0.88 | FLT1 (0.53) | FLT1KDRFGFR1FLT4EGFR | |
| SCHEMBL6434691 | 0.85 | FLT1 (0.69) | FLT1KDRFGFR1FLT4EGFR | |
| SCHEMBL6432228 | 0.85 | FLT1 (0.61) | FLT1KDRFGFR1FLT4EGFR | |
| SCHEMBL6435236 | 0.85 | FGFR1 (0.57) | FLT1KDRFGFR1FLT4EGFR | |
| SCHEMBL6431414 | 0.83 | KDR (0.60) | FLT1KDRFGFR1FLT4EGFR | |
| SCHEMBL6430845 | 0.82 | FLT1 (0.55) | FLT1KDRFGFR1FLT4FGFR2 | |
| SCHEMBL6431198 | 0.80 | FLT1 (1.00) | FLT1KDRFGFR1FLT4EGFR | |
| Hydrochloric Acid SCHEMBL6431524 | 0.80 | FLT1 (0.98) | FLT1KDRFGFR1FLT4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | claimed |