Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8906815 | 0.81 | PLA2G7 (0.59) | PLA2G7AURKAAURKBALDH1A1CYP1A2 | |
| SCHEMBL715948 | 0.74 | PLA2G7 (0.52) | PLA2G7AURKAAURKBALDH1A1CYP1A2 | |
| SCHEMBL4934858 | 0.74 | FADS1 (0.30) | — | |
| SCHEMBL27675533 | 0.73 | PLA2G7 (0.49) | PLA2G7AURKAAURKBALDH1A1CYP1A2 | |
| SCHEMBL716169 | 0.72 | NPC1 (0.56) | PLA2G7AURKAAURKBALDH1A1CYP1A2 | |
| SCHEMBL720796 | 0.72 | PLA2G7 (0.45) | PLA2G7AURKAAURKBALDH1A1CYP1A2 | |
| SCHEMBL3042388 | 0.71 | MBD2 (0.55) | PLA2G7AURKAALDH1A1CYP1A2MEN1 | |
| SCHEMBL3956903 | 0.71 | MEN1 (0.65) | PLA2G7ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL4238370 | 0.71 | PLA2G7 (0.60) | PLA2G7ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL13548282 | 0.71 | PLA2G7 (0.52) | PLA2G7AURKAAURKBCYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239852-A1 | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors | AB SCIENCE (FR) | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239852-A1 | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors | KIT, CHUK, MAP3K2 | PLA2G7 2034/4885AURKA 117/4885AURKB 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.