Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 10/20 | 0.64 |
| ▸ | EHMT1 | Q9H9B1 | 10/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.60 |
| ▸ | FLT1 | P17948 | 4/20 | 0.60 |
| ▸ | RET | P07949 | 6/20 | 0.58 |
| ▸ | KIF5B | P33176 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6430760 | 0.99 | EHMT2 (0.63) | EHMT2EHMT1FGFR1FLT1RET | |
| SCHEMBL6431249 | 0.93 | RET (0.60) | EHMT2EHMT1FGFR1FLT1RET | |
| Hydrochloric Acid SCHEMBL6434957 | 0.91 | RET (0.58) | EHMT2EHMT1FGFR1FLT1RET | |
| SCHEMBL6431147 | 0.91 | FLT1 (0.75) | EHMT2EHMT1FGFR1FLT1RET | |
| Hydrochloric Acid SCHEMBL6432102 | 0.90 | FLT1 (0.73) | EHMT2EHMT1FGFR1FLT1RET | |
| SCHEMBL6096842 | 0.87 | FLT1 (0.61) | EHMT2EHMT1FGFR1FLT1RET | |
| SCHEMBL6430841 | 0.85 | FLT1 (0.80) | FGFR1FLT1RETKIF5BKDR | |
| SCHEMBL6434212 | 0.85 | KDR (0.68) | FGFR1FLT1RETKIF5BKDR | |
| Hydrochloric Acid SCHEMBL6431075 | 0.85 | FLT1 (0.79) | FGFR1FLT1RETKIF5BKDR | |
| SCHEMBL6430749 | 0.84 | FGFR1 (0.75) | EHMT2EHMT1FGFR1FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | claimed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | claimed |
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |