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SCHEMBL6431959

SCHEMBL6431959

O=C(NCc1ccc(S(=O)(=O)N2CCN(CCc3ccccc3)CC2)s1)c1ccc(Cl)cc1.O=C(NCc1ccc(S(=O)(=O)N2CCN(Cc3ccccc3)CC2)s1)c1ccc(Cl)cc1

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ MAPK9 P45984 1/20 0.55
▸ MAPK10 P53779 1/20 0.55
▸ MEN1 O00255 4/20 0.53
▸ KMT2A Q03164 4/20 0.53
▸ LMNA P02545 2/20 0.53
▸ SMN1; SMN2 Q16637 2/20 0.53
▸ BCL2 P10415 1/20 0.53
▸ BCL2L1 Q07817 1/20 0.53
▸ MAPK1 P28482 1/20 0.53
▸ ALDH1A1 P00352 3/20 0.47
▸ USP2 O75604 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3479899 0.97 MAPK9 (0.57) MAPK9MAPK10MEN1KMT2ALMNA
SCHEMBL7439629 0.95 MAPK9 (0.51) MAPK9MAPK10MEN1KMT2ALMNA
SCHEMBL3480648 0.95 MAPK9 (0.60) MAPK9MAPK10MEN1KMT2ALMNA
SCHEMBL2423789 0.92 MAPK9 (0.56) MAPK9MAPK10MEN1KMT2ALMNA
SCHEMBL3480113 0.85 MAPK9 (0.54) MAPK9MAPK10MEN1KMT2ALMNA
SCHEMBL2421342 0.85 MAPK9 (0.56) MAPK9MAPK10MEN1KMT2ALMNA
SCHEMBL2425245 0.85 MAPK9 (0.54) MAPK9MAPK10MEN1KMT2ALMNA
SCHEMBL2426839 0.84 MEN1 (0.53) MAPK9MAPK10MEN1KMT2ALMNA
SCHEMBL2424773 0.84 MAPK9 (0.63) MAPK9MAPK10MEN1KMT2ALMNA
SCHEMBL7434542 0.84 DRD2 (0.58) MAPK9MAPK10MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218374-B1 PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES APPLIED RESEARCH SYSTEMS (AN) 2005-11-16 — — EP claimed
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