Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | RAB7A | P51149 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029267 | 0.87 | KMT2A (0.33) | KMT2ANOD1POLBCASP6RAB7A | |
| SCHEMBL7849798 | 0.73 | KMT2A (0.38) | KMT2ANOD1POLB | |
| SCHEMBL7855098 | 0.73 | PTPN2 (0.58) | KMT2ANOD1POLBCASP6PTPN1 | |
| SCHEMBL7693899 | 0.73 | PTPN1 (0.53) | KMT2ANOD1POLBCASP6PTPN1 | |
| SCHEMBL7031718 | 0.72 | ALDH1A1 (0.40) | POLB | |
| SCHEMBL7854135 | 0.70 | PTPN1 (0.58) | KMT2ANOD1POLBCASP6RAB7A | |
| SCHEMBL6437604 | 0.69 | PTPN1 (0.38) | POLBPTPN1 | |
| SCHEMBL4449756 | 0.69 | PTPN1 (0.55) | KMT2ANOD1POLBCASP6PTPN1 | |
| SCHEMBL6432093 | 0.69 | PTPN2 (0.34) | POLBPTPN1 | |
| SCHEMBL7167862 | 0.68 | NPSR1 (0.52) | KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404682-B1 | METHOD OF INHIBITING PTP 1B AND/OR T-CELL PTP AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK AS (DK) | 2005-09-14 | — | — | EP | disclosed |
| US-20030064979-A1 | Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2003-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030064979-A1 | Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48 | PTPRO, PTPRF, PTPA | KMT2A 3893/4885NOD1 1041/4885POLB 1573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.