Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 7/20 | 0.48 |
| ▸ | CNR1 | P21554 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432441 | 0.90 | F10 (0.58) | CCR2ROCK2F10CNR1 | |
| SCHEMBL6436677 | 0.84 | F10 (0.59) | CCR2ROCK2F10CNR1NPY5R | |
| SCHEMBL6436698 | 0.83 | F10 (0.66) | CCR2F10CNR1 | |
| SCHEMBL6434131 | 0.82 | F10 (0.59) | F10 | |
| SCHEMBL6432886 | 0.81 | F10 (0.56) | CCR2F10CNR1 | |
| SCHEMBL6433060 | 0.81 | F10 (0.71) | CCR2F10CNR1 | |
| SCHEMBL6432496 | 0.81 | F10 (0.62) | CCR2F10CNR1 | |
| SCHEMBL7712483 | 0.81 | F10 (0.53) | CCR2F10CNR1 | |
| SCHEMBL6434800 | 0.80 | CCR2 (0.53) | CCR2F10CNR1 | |
| SCHEMBL6436901 | 0.79 | F10 (0.69) | CCR2F10CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042287-B1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | AVENTIS PHARMA GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| US-6337344-B1 | ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-08 | — | — | US | disclosed |
| EP-1042287-A1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | Aventis Pharma Deutschland GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033800-A1 | INDOLE DERIVATIVES AS INHIBITORS OR FACTOR XA | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-08 | — | — | WO | disclosed |