Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 10/20 | 0.59 |
| ▸ | ADRB3 | P13945 | 10/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432407 | 1.00 | ADRB1 (0.59) | ADRB1ADRB3ADRB2CYP1A2MEN1 | |
| SCHEMBL6434607 | 0.91 | ADRB1 (0.61) | ADRB1ADRB3ADRB2CYP1A2MEN1 | |
| SCHEMBL6434599 | 0.91 | ADRB1 (0.61) | ADRB1ADRB3ADRB2CYP1A2MEN1 | |
| SCHEMBL6440250 | 0.87 | ADRB1 (0.51) | ADRB1ADRB3ADRB2CYP1A2MEN1 | |
| SCHEMBL11244044 | 0.81 | MAPT (0.69) | ADRB1ADRB3ADRB2CYP1A2MEN1 | |
| SCHEMBL11234633 | 0.81 | MEN1 (0.55) | ADRB1ADRB3ADRB2CYP1A2MEN1 | |
| SCHEMBL11246086 | 0.81 | MAPT (0.63) | ADRB1ADRB3ADRB2CYP1A2MEN1 | |
| Hydrochloric Acid SCHEMBL11230526 | 0.80 | MAPT (0.68) | ADRB1ADRB3ADRB2CYP1A2MEN1 | |
| SCHEMBL11237809 | 0.80 | MEN1 (0.54) | ADRB1ADRB3ADRB2CYP1A2MEN1 | |
| SCHEMBL11238941 | 0.80 | ATM (0.56) | ADRB1ADRB3ADRB2CYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087943-B1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-08-17 | — | — | EP | claimed |
| EP-1087943-B1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| US-6251925-B1 | AN AGONISTS FOR HUMAN BETA-3 ADRENOCEPTOR | GLAXO WELLCOME INC. | 2001-06-26 | — | — | US | disclosed |