Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.62 |
| ▸ | THRB | P10828 | 7/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798722 | 0.90 | THRA (0.76) | THRATHRB | |
| SCHEMBL6432405 | 0.88 | THRA (0.80) | THRATHRB | |
| SCHEMBL8799433 | 0.81 | THRA (0.80) | THRATHRB | |
| SCHEMBL6658658 | 0.81 | THRA (0.67) | THRATHRB | |
| SCHEMBL5396885 | 0.78 | THRB (0.79) | THRATHRB | |
| SCHEMBL6435035 | 0.78 | THRA (0.66) | THRATHRB | |
| SCHEMBL29373673 | 0.77 | THRA (1.00) | THRATHRB | |
| SCHEMBL281877 | 0.77 | THRA (1.00) | THRATHRB | |
| SCHEMBL4964894 | 0.77 | THRA (0.78) | THRATHRB | |
| SCHEMBL8800061 | 0.77 | THRA (0.86) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033364-B1 | Cyano containing oxamic acids and derivatives as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-02-23 | — | — | EP | disclosed |
| US-6194454-B1 | ANTILIPEMIC AGENTS; ANTIDIABETIC AGENTS; DIETETICS; RHEUMATIC DISEASES; ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS; ANTIDEPRESSANTS; BONE DISORDERS | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1033364-A1 | Cyano containing oxamic acids and derivatives as thyroid receptor ligands | Pfizer Products Inc. (US) | 2000-09-06 | — | — | EP | disclosed |