SCHEMBL6432997

SCHEMBL6432997

CC(=O)c1ccc(OCC=C(C)C)cc1O

nearest known ligand 0.81

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 17/20 0.64
ALDH1A1 P00352 1/20 0.58
CYP3A4 P08684 1/20 0.58
HPGD P15428 1/20 0.58
MAPK1 P28482 1/20 0.58
MAOA P21397 6/20 0.57
PPARD Q03181 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3901893 0.86 ALOX5 (0.58) MAOBALDH1A1HPGD
SCHEMBL8151695 0.84 MAOB (0.60) MAOBALDH1A1CYP3A4HPGDMAPK1
SCHEMBL5519287 0.84 MAOB (0.53) MAOBALDH1A1HPGD
SCHEMBL30887139 0.83 MAOB (0.67) MAOBALDH1A1CYP3A4HPGDMAPK1
SCHEMBL11050615 0.83 MAOB (0.58) MAOBALDH1A1CYP3A4HPGDMAPK1
SCHEMBL8160559 0.83 MAOB (0.58) MAOBALDH1A1CYP3A4HPGDMAPK1
SCHEMBL30384031 0.81 MAOB (0.89) MAOBALDH1A1CYP3A4HPGDMAPK1
SCHEMBL11394919 0.81 MAOB (0.89) MAOBALDH1A1CYP3A4HPGDMAPK1
SCHEMBL11394922 0.81 MAOB (0.89) MAOBALDH1A1CYP3A4HPGDMAPK1
SCHEMBL9364600 0.81 MEN1 (0.70) MAOBALDH1A1HPGDPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5058885-A None JP disclosed
EP-0989973-B1 CHALCONES HAVING ANTIPROLIFERATIVE ACTIVITY INDENA SPA (IT) 2005-08-31 EP disclosed
US-6423740-B1 ANTICARCINOGENIC AGENTS INDENA S.P.A. (IT) 2002-07-23 US disclosed
US-6147082-A 1,3-DIPHENYL-2-PROPENE-1-ONE DERIVATIVES; TREATING OR PREVENTING NEOPLASMS, MENOPAUSAL DISORDERS, AND OSTEOPOROSIS IN A MAMMAL INDENA S.P.A (IT) 2000-11-14 US disclosed
EP-0989973-A1 CHALCONES HAVING ANTIPROLIFERATIVE ACTIVITY INDENA S.p.A. (IT) 2000-04-05 EP disclosed
WO-1998058913-A1 CHALCONES HAVING ANTIPROLIFERATIVE ACTIVITY INDENA S.P.A. (IT) 1998-12-30 WO disclosed
EP-0412803-B1 Chalcone derivatives TAISHO PHARMACEUTICAL CO LTD (JP) 1994-03-23 EP disclosed
JP-H0558885-A ANTIULCER AGENT TAISHO PHARMACEUT CO LTD 1993-03-09 JP disclosed
US-5089654-A Antiulcer agents TAISHO PHARMACEUTICAL CO., LTD. (JP) 1992-02-18 US disclosed
EP-0412803-A1 Chalcone derivatives TAISHO PHARMACEUTICAL CO. LTD (JP) 1991-02-13 EP disclosed
US-RE33109-E ANTIULCER, ANTIINFLAMMATORY BIOREX LABORATORIES LIMITED (GB) 1989-11-07 US disclosed
US-4656305-A ANTIINFLAMMATORY AND ANTIULCER AGENTS; ANTIALLERGENS; ANALGESICS BIOREX LABORATORIES, LIMITED (GB) 1987-04-07 US disclosed
US-4085135-A ANTIULCER TAISHO PHARMACEUTICAL CO., LTD. (JA) 1978-04-18 US disclosed