Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Chlorhexidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorhexidine SCHEMBL6437831 | 1.00 | LMNA (0.45) | LMNASMN1; SMN2HDAC8CNR1MEN1 | |
| Chlorhexidine SCHEMBL2152631 | 1.00 | LMNA (0.45) | LMNASMN1; SMN2HDAC8CNR1MEN1 | |
| Chlorhexidine SCHEMBL1550787 | 0.98 | LMNA (0.46) | LMNASMN1; SMN2HDAC8CNR1MEN1 | |
| Chlorhexidine SCHEMBL3984 | 0.98 | LMNA (0.46) | LMNASMN1; SMN2HDAC8CNR1MEN1 | |
| SCHEMBL6365499 | 0.98 | LMNA (0.46) | LMNASMN1; SMN2HDAC8CNR1MEN1 | |
| Chlorhexidine SCHEMBL1551122 | 0.98 | LMNA (0.46) | LMNASMN1; SMN2HDAC8CNR1MEN1 | |
| Chlorhexidine SCHEMBL23117798 | 0.97 | LMNA (0.45) | LMNASMN1; SMN2HDAC8CNR1MEN1 | |
| Chlorhexidine SCHEMBL10808378 | 0.97 | SMN1; SMN2 (0.45) | LMNASMN1; SMN2HDAC8CNR1MEN1 | |
| Chlorhexidine SCHEMBL21226467 | 0.97 | LMNA (0.45) | LMNASMN1; SMN2HDAC8CNR1MEN1 | |
| Chlorhexidine SCHEMBL1147274 | 0.97 | LMNA (0.45) | LMNASMN1; SMN2HDAC8CNR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108484571-B | Salts and solid forms of compounds, compositions comprising the same and methods of use thereof | 细胞基因公司 | 2021-08-17 | — | — | CN | disclosed |
| US-6844306-B2 | Water-soluble, chlorhexidine-containing compositions and use thereof | DEGUSSA AG (DE) | 2005-01-18 | — | — | US | disclosed |
| US-20020072480-A1 | Water-soluble, chlorhexidine-containing compositions and use thereof | DEGUSSA AG (DE) | 2002-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020072480-A1 | Water-soluble, chlorhexidine-containing compositions and use thereof | SI, PEF1, MGAM | SLC6A3 3425/4885LMNA 2666/4885SMN1; SMN2 3813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.