Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27915406 | 0.84 | DDR1 (0.46) | DDR1HPGDF2RKDM4EGAA | |
| SCHEMBL9907157 | 0.83 | GSK3B (0.56) | DDR1HPGDF2RKDM4EGAA | |
| SCHEMBL22570651 | 0.83 | DDR1 (0.42) | DDR1CES2CES1HPGDF2R | |
| SCHEMBL2236310 | 0.81 | DDR1 (0.44) | DDR1HPGDF2RKDM4EGAA | |
| Hydrochloric Acid SCHEMBL29393523 | 0.81 | DDR1 (0.41) | DDR1HPGDF2RKDM4EGAA | |
| Hydrochloric Acid SCHEMBL22556876 | 0.81 | DDR1 (0.41) | DDR1HPGDF2RKDM4EGAA | |
| SCHEMBL30666356 | 0.80 | ALDH1A1 (0.55) | DDR1HPGDKMT2A | |
| SCHEMBL31130288 | 0.79 | KCNH2 (0.45) | DDR1KDM4EGAAMEN1KMT2A | |
| SCHEMBL30251625 | 0.78 | TPMT (0.61) | DDR1HPGDKDM4EFFAR2 | |
| SCHEMBL1188363 | 0.78 | LMNA (0.47) | DDR1CES2CES1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1514550-A2 | Combinations for diabetes which contain a sulfonylurea, a glitazone and a biguanide | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-16 | — | — | EP | disclosed |
| EP-1128834-A1 | COMBINATIONS FOR DIABETES WHICH CONTAIN A SULFONYLUREA, A GLITAZONE AND A BIGUANIDE | WARNER-LAMBERT COMPANY (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027401-A1 | COMBINATIONS FOR DIABETES WHICH CONTAIN A SULFONYLUREA, A GLITAZONE AND A BIGUANIDE | WARNER-LAMBERT COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |
| US-6011049-A | Combinations for diabetes | WARNER-LAMBERT COMPANY (US) | 2000-01-04 | — | — | US | disclosed |
| EP-0957923-A1 | SULFONYLUREA-GLITAZONE SYNERGISTIC COMBINATIONS FOR DIABETES | WARNER-LAMBERT COMPANY (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5972973-A | SYNERGISTIC MIXTURE; GLUCOSE CONTROL | WARNER-LAMBERT COMPANY (US) | 1999-10-26 | — | — | US | disclosed |
| US-5859037-A | MIXTURE SYNERGISTIC FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS IN HUMANS, WHICH ALSO IMPROVES GLYCEMIC CONTROL | WARNER-LAMBERT COMPANY (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1998036755-A1 | SULFONYLUREA-GLITAZONE SYNERGISTIC COMBINATIONS FOR DIABETES | WARNER LAMBERT COMPANY (US) | 1998-08-27 | — | — | WO | disclosed |