Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.53 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.51 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.51 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.51 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.51 |
| ▸ | CBFB | Q13951 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20741514 | 0.88 | KDM4E (0.64) | NPC1MAPTKDM4ERAB9AMEN1 | |
| SCHEMBL20292801 | 0.88 | MALT1 (0.58) | NPC1MAPTKDM4ERAB9AMEN1 | |
| SCHEMBL21241308 | 0.83 | NPC1 (0.54) | NPC1MAPTKDM4ERAB9AMEN1 | |
| SCHEMBL31054236 | 0.81 | MAOA (0.55) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL22926876 | 0.81 | MALT1 (0.49) | MALT1EGFRKDR | |
| SCHEMBL29659720 | 0.81 | MALT1 (0.49) | MALT1EGFRKDR | |
| SCHEMBL15447361 | 0.80 | MAP4K4 (0.46) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL27883828 | 0.79 | EGFR (0.57) | NPC1MEN1KMT2APABPC1MALT1 | |
| SCHEMBL12298751 | 0.77 | MEN1 (0.56) | NPC1MAPTKDM4ERAB9AMEN1 | |
| SCHEMBL15690282 | 0.76 | KDM4E (0.56) | NPC1MAPTKDM4ERAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1680418-A | Ketolactones, their use and process for their preparation and pharmaceutical compositions containing them | ABBOTT LAB (US) | 2005-10-12 | — | — | CN | disclosed |
| CN-1680419-A | Ketolactones, their use and process for their preparation and pharmaceutical compositions containing them | ABBOTT LAB (US) | 2005-10-12 | — | — | CN | disclosed |
| CN-1680420-A | Ketolactones, their use and process for their preparation and pharmaceutical compositions containing them | ABBOTT LAB (US) | 2005-10-12 | — | — | CN | disclosed |
| EP-1291351-B1 | 6-0 substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-0929563-B1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LAB (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1291353-B1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1291352-B1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1291350-B1 | 6-0 substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1291353-A1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1291352-A1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1291350-A1 | 6-0 substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1291351-A1 | 6-0 substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2003-03-12 | — | — | EP | disclosed |