Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2399133 | 0.85 | AVPR1A (0.45) | AVPR1AJAK2JAK1ALDH1A1LMNA | |
| SCHEMBL6415557 | 0.84 | KMT2A (0.45) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL6431092 | 0.84 | AVPR1A (0.41) | AVPR1AJAK2JAK1ALDH1A1LMNA | |
| SCHEMBL6410357 | 0.80 | POLB (0.43) | ALDH1A1LMNAPOLBHTT | |
| SCHEMBL6411397 | 0.78 | ALDH1A1 (0.42) | ALDH1A1LMNAHTTMEN1KMT2A | |
| SCHEMBL6409874 | 0.77 | FASN (0.40) | KMT2A | |
| SCHEMBL6413248 | 0.74 | AVPR1A (0.54) | AVPR1AJAK2JAK1ALDH1A1LMNA | |
| SCHEMBL6410188 | 0.73 | MEN1 (0.45) | ALDH1A1LMNAHTTMEN1KMT2A | |
| SCHEMBL6410103 | 0.73 | CYP2D6 (0.42) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6410008 | 0.72 | DRD2 (0.39) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |