Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 6/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.59 |
| ▸ | EGFR | P00533 | 6/20 | 0.51 |
| ▸ | KDR | P35968 | 8/20 | 0.50 |
| ▸ | GAK | O14976 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 4/20 | 0.47 |
| ▸ | KIF5B | P33176 | 4/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8509837 | 1.00 | FLT1 (0.59) | FLT1FGFR1EGFRKDRGAK | |
| Hydrochloric Acid SCHEMBL6432639 | 0.99 | FLT1 (0.58) | FLT1FGFR1EGFRKDRGAK | |
| SCHEMBL6433759 | 0.89 | FLT1 (0.65) | FLT1FGFR1EGFRKDRGAK | |
| SCHEMBL6430998 | 0.89 | FLT1 (0.75) | FLT1FGFR1EGFRKDRRET | |
| Hydrochloric Acid SCHEMBL6431427 | 0.88 | FLT1 (0.74) | FLT1FGFR1EGFRKDRRET | |
| SCHEMBL27530363 | 0.85 | EGFR (0.47) | FLT1FGFR1EGFRKDRMET | |
| Hydrochloric Acid SCHEMBL27532303 | 0.84 | EGFR (0.46) | FLT1FGFR1EGFRKDRMET | |
| SCHEMBL6436593 | 0.83 | MEN1 (0.43) | FLT1FGFR1EGFRKDRRAF1 | |
| SCHEMBL6998899 | 0.82 | FLT1 (0.74) | FLT1FGFR1EGFRKDRSRC | |
| SCHEMBL6433880 | 0.81 | FLT1 (0.75) | FLT1FGFR1EGFRKDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1252054-C | Qinoline derivatives inhibiting effect of growth factors such as VEGF | ZENECA LTD (GB) | 2006-04-19 | — | — | CN | claimed |
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | claimed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | claimed |
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |