Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 8/20 | 0.64 |
| ▸ | CCR9 | P51686 | 4/20 | 0.61 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6440148 | 0.91 | MAPT (0.53) | CCR2CCR9MTNR1AMTNR1BPIK3R1 | |
| SCHEMBL3965499 | 0.88 | CCR2 (0.73) | CCR2CCR9MTNR1AMTNR1BGPR35 | |
| SCHEMBL6433076 | 0.83 | CCR2 (0.77) | CCR2CCR9GPR35 | |
| SCHEMBL6434144 | 0.81 | F10 (0.52) | CCR2CCR9MTNR1AMTNR1B | |
| SCHEMBL31689637 | 0.80 | CCR9 (0.56) | CCR2CCR9GPR35GRIN1GRIN2B | |
| SCHEMBL21822295 | 0.80 | CCR9 (0.56) | CCR2CCR9GPR35GRIN1GRIN2B | |
| SCHEMBL6433546 | 0.80 | CCR2 (0.67) | CCR2CCR9MTNR1AMTNR1BPIK3R1 | |
| SCHEMBL6432803 | 0.79 | CCR2 (0.70) | CCR2GPR35 | |
| SCHEMBL6307840 | 0.79 | CCR2 (0.67) | CCR2CCR9GPR35 | |
| SCHEMBL21822281 | 0.79 | CCR9 (0.69) | CCR2CCR9GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042287-B1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | AVENTIS PHARMA GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| US-6337344-B1 | ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-08 | — | — | US | disclosed |
| EP-1042287-A1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | Aventis Pharma Deutschland GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033800-A1 | INDOLE DERIVATIVES AS INHIBITORS OR FACTOR XA | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-08 | — | — | WO | disclosed |