Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 9/20 | 0.56 |
| ▸ | ACE | P12821 | 8/20 | 0.56 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.48 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424465 | 1.00 | FKBP1A (0.56) | FKBP1AACECTRB1MMEL1ACE2 | |
| SCHEMBL10404568 | 0.89 | ACE (0.53) | FKBP1AACECTRB1 | |
| SCHEMBL6438368 | 0.87 | ACE (0.58) | ACEACE2 | |
| SCHEMBL6438372 | 0.87 | ACE (0.58) | ACEACE2 | |
| SCHEMBL8378226 | 0.87 | ACE (0.58) | ACEACE2 | |
| SCHEMBL6439093 | 0.86 | ACE (0.62) | FKBP1AACECTRB1ACE2 | |
| SCHEMBL6436340 | 0.82 | ACE (0.59) | FKBP1AACEMMEL1ACE2 | |
| SCHEMBL7426069 | 0.82 | ACE (0.59) | FKBP1AACEMMEL1ACE2 | |
| SCHEMBL7148899 | 0.82 | ACE (0.63) | FKBP1AACE | |
| SCHEMBL7537159 | 0.82 | ACE (0.63) | FKBP1AACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1505062-A1 | Heterocyclic derivatives and their use as antithrombotic agents | Akzo Nobel N.V. (NL) | 2005-02-09 | — | — | EP | disclosed |
| US-6797710-B2 | CARDIOVASCULAR DISORDERS; SERINE PROTEASE INHIBITOR; ADMINISTERING BY MOUTH; BIOAVAILABILITY | AKZO NOBEL N.V. (NL) | 2004-09-28 | — | — | US | disclosed |
| US-20030130270-A1 | Heterocyclic derivatives and their use as antithrombotic agents | MERCK SHARP & DOHME B.V. (NL) | 2003-07-10 | — | — | US | disclosed |
| US-6444672-B1 | ORAL BIOVAILABILITY; INHIBITORS OF THROMBIN AND/OR FACTOR XA; SERINE PROTEASE INHIBITOR | AKZO NOBEL N.V. (NL) | 2002-09-03 | — | — | US | disclosed |
| US-6432955-B1 | ANTICOAGULANTS | AKZO NOBEL N.V. (NL) | 2002-08-13 | — | — | US | disclosed |
| US-6194409-B1 | SERINE PROTEASE INHIBITOR; BIOAVAILABILITY WHEN ADMINISTERED BY MOUTH | AKZO NOBEL N.V. (NL) | 2001-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130270-A1 | Heterocyclic derivatives and their use as antithrombotic agents | F2, F12, VKORC1 | FKBP1A 2551/4885ACE 234/4885CTRB1 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.