Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.51 |
| ▸ | FLT1 | P17948 | 8/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 10/20 | 0.48 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431180 | 0.96 | EGFR (0.55) | EGFRFLT1FGFR1KDRSRC | |
| SCHEMBL6432660 | 0.90 | FLT1 (0.51) | EGFRFLT1FGFR1KDRSRC | |
| SCHEMBL6432008 | 0.87 | FLT1 (0.46) | EGFRFLT1FGFR1KDRSRC | |
| SCHEMBL7451650 | 0.86 | EGFR (0.54) | EGFRFLT1FGFR1KDRSRC | |
| SCHEMBL6431462 | 0.86 | FLT1 (0.51) | EGFRFLT1FGFR1KDRSRC | |
| SCHEMBL6431014 | 0.83 | EGFR (0.50) | EGFRFLT1FGFR1KDRSRC | |
| SCHEMBL6434966 | 0.83 | FLT1 (0.51) | EGFRFLT1FGFR1KDRSRC | |
| SCHEMBL8509887 | 0.82 | SRC (0.43) | EGFRFLT1FGFR1KDRSRC | |
| SCHEMBL7450324 | 0.81 | KDR (0.63) | EGFRFLT1FGFR1KDRSRC | |
| SCHEMBL6433880 | 0.79 | FLT1 (0.75) | EGFRFLT1FGFR1KDRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |