Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 6/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.51 |
| ▸ | KDR | P35968 | 11/20 | 0.43 |
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431005 | 0.93 | FLT1 (0.51) | FLT1FGFR1KDRRAF1BRAF | |
| SCHEMBL6434691 | 0.86 | FLT1 (0.69) | FLT1FGFR1KDRRAF1BRAF | |
| SCHEMBL6432190 | 0.84 | FLT1 (0.49) | FLT1FGFR1KDRRAF1BRAF | |
| SCHEMBL6431596 | 0.83 | FLT1 (0.47) | FLT1FGFR1KDRRAF1BRAF | |
| SCHEMBL6433880 | 0.83 | FLT1 (0.75) | FLT1FGFR1KDRRAF1BRAF | |
| SCHEMBL6431015 | 0.82 | FLT1 (0.51) | FLT1FGFR1KDRRAF1BRAF | |
| SCHEMBL6436593 | 0.82 | MEN1 (0.43) | FLT1FGFR1KDRRAF1BRAF | |
| Hydrochloric Acid SCHEMBL6430947 | 0.82 | FLT1 (0.74) | FLT1FGFR1KDRRAF1BRAF | |
| SCHEMBL6431154 | 0.80 | FLT1 (0.52) | FLT1FGFR1KDRFLT4FGFR2 | |
| SCHEMBL6436287 | 0.79 | RET (0.54) | FLT1FGFR1KDRBRAFFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | claimed |