Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | CTSV | O60911 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431005 | 0.89 | FLT1 (0.51) | MEN1KMT2AMAPTKDRFGFR1 | |
| SCHEMBL8509837 | 0.83 | FLT1 (0.59) | MEN1KMT2AMAPTKDRFGFR1 | |
| SCHEMBL6434776 | 0.83 | FLT1 (0.59) | MEN1KMT2AMAPTKDRFGFR1 | |
| SCHEMBL6434993 | 0.82 | FLT1 (0.51) | MEN1KMT2AMAPTKDRFGFR1 | |
| Hydrochloric Acid SCHEMBL6432639 | 0.82 | FLT1 (0.58) | MEN1KMT2AMAPTKDRFGFR1 | |
| SCHEMBL6450143 | 0.79 | CTSV (0.45) | MEN1KMT2AMAPTKDRCTSV | |
| SCHEMBL6430845 | 0.76 | FLT1 (0.55) | MEN1KMT2AMAPTKDRFGFR1 | |
| SCHEMBL6434691 | 0.75 | FLT1 (0.69) | KDRFGFR1FLT1RAF1BRAF | |
| SCHEMBL6432190 | 0.74 | FLT1 (0.49) | KMT2AKDRFGFR1FLT1RAF1 | |
| SCHEMBL6431015 | 0.74 | FLT1 (0.51) | KDRFGFR1FLT1RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | claimed |