Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432711 | 1.00 | ALDH1A1 (0.46) | ALDH1A1CYP1A2KMT2AMEN1RAB9A | |
| SCHEMBL638444 | 0.83 | ALDH1A1 (0.63) | ALDH1A1CYP1A2KMT2AMEN1RAB9A | |
| SCHEMBL6433589 | 0.83 | MAPT (0.46) | ALDH1A1CYP1A2KMT2AMEN1RAB9A | |
| SCHEMBL2880324 | 0.82 | KMT2A (0.57) | ALDH1A1KMT2AMEN1HTTCNR1 | |
| SCHEMBL2874789 | 0.82 | SLC6A3 (0.52) | ALDH1A1KMT2AMEN1NPC1GAA | |
| Hydrochloric Acid SCHEMBL31522191 | 0.81 | ALDH1A1 (0.50) | ALDH1A1CYP1A2KMT2AMEN1RAB9A | |
| Hydrochloric Acid SCHEMBL29221336 | 0.80 | ALDH1A1 (0.49) | ALDH1A1CYP1A2KMT2AMEN1RAB9A | |
| SCHEMBL5205156 | 0.76 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL6431539 | 0.75 | ALDH1A1 (0.44) | ALDH1A1CYP1A2KMT2AMEN1GAA | |
| SCHEMBL6431542 | 0.75 | ALDH1A1 (0.44) | ALDH1A1CYP1A2KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224163-B1 | USE OF CARBONYLAMINO DERIVATIVES AGAINST CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2005-03-30 | — | — | EP | disclosed |
| US-6548522-B1 | N-substituted 2,2-diphenylacetamide or N-substituted 2-phenyl-2-pyridinylacetamide | HOFFMANN-LA ROCHE INC. | 2003-04-15 | — | — | US | disclosed |
| EP-1224163-A1 | USE OF CARBONYLAMINO DERIVATIVES AGAINST CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027070-A1 | USE OF CARBONYLAMINO DERIVATIVES AGAINST CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-19 | — | — | WO | disclosed |