Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.54 |
| ▸ | FLT1 | P17948 | 5/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | KIF5B | P33176 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 5/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 3/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.42 |
| ▸ | COQ8A | Q8NI60 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6434934 | 0.99 | KDR (0.53) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL6431742 | 0.89 | FLT1 (0.61) | KDRFLT1FGFR1RETKIF5B | |
| Hydrochloric Acid SCHEMBL6431020 | 0.89 | FLT1 (0.61) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL6434212 | 0.88 | KDR (0.68) | KDRFLT1FGFR1RETKIF5B | |
| Hydrochloric Acid SCHEMBL6434300 | 0.87 | KDR (0.67) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL6434267 | 0.82 | KDR (0.54) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL6430841 | 0.81 | FLT1 (0.80) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL6430668 | 0.80 | SRC (0.49) | RETKIF5BSRCEGFRERBB2 | |
| Hydrochloric Acid SCHEMBL6431075 | 0.80 | FLT1 (0.79) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL6433759 | 0.76 | FLT1 (0.65) | KDRFLT1FGFR1RETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | claimed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | claimed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | claimed |
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |