Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 15/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 15/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 11/20 | 0.43 |
| ▸ | CASR | P41180 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6435848 | 0.97 | ADRB1 (0.45) | ADRB1ADRB3ADRB2CASR | |
| SCHEMBL6432460 | 0.92 | ADRB3 (0.52) | ADRB1ADRB3ADRB2CASR | |
| SCHEMBL6432465 | 0.92 | ADRB3 (0.52) | ADRB1ADRB3ADRB2CASR | |
| SCHEMBL6436830 | 0.89 | ADRB1 (0.42) | ADRB1ADRB3ADRB2CASR | |
| SCHEMBL6432983 | 0.87 | ADRB1 (0.43) | ADRB1ADRB3ADRB2CASR | |
| SCHEMBL6437274 | 0.87 | ADRB1 (0.43) | ADRB1ADRB3ADRB2CASR | |
| SCHEMBL6433728 | 0.87 | ADRB1 (0.45) | ADRB1ADRB3ADRB2CASR | |
| SCHEMBL6436834 | 0.87 | ADRB1 (0.40) | ADRB1ADRB3ADRB2 | |
| SCHEMBL6433735 | 0.87 | ADRB1 (0.45) | ADRB1ADRB3ADRB2CASR | |
| SCHEMBL6435850 | 0.86 | ADRB2 (0.47) | ADRB1ADRB3ADRB2CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087943-B1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| US-6251925-B1 | AN AGONISTS FOR HUMAN BETA-3 ADRENOCEPTOR | GLAXO WELLCOME INC. | 2001-06-26 | — | — | US | disclosed |
| EP-1087943-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065877-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-12-23 | — | — | WO | disclosed |