Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | CASP1 | P29466 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 4/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 4/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 4/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6909986 | 0.95 | GPR174 (0.56) | GPR174KDM4EGAAHSD17B10HPGD | |
| SCHEMBL6434638 | 0.87 | GAA (0.59) | GPR174KDM4EGAAHSD17B10HPGD | |
| SCHEMBL6907896 | 0.83 | GPR174 (0.55) | GPR174KDM4EGAAALDH1A1ABCC9 | |
| SCHEMBL6908858 | 0.82 | GAA (0.59) | GPR174KDM4EGAAHSD17B10HPGD | |
| SCHEMBL6909423 | 0.81 | KDM4E (0.54) | KDM4EHSD17B10HPGDALDH1A1ABCC9 | |
| SCHEMBL6431674 | 0.81 | ABCC9 (0.61) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6432586 | 0.81 | ABCC9 (0.61) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6432083 | 0.81 | ABCC9 (0.61) | KDM4EGAAHSD17B10ALDH1A1LMNA | |
| SCHEMBL6903824 | 0.81 | ABCC9 (0.61) | KDM4EGAAHSD17B10ALDH1A1LMNA | |
| SCHEMBL6903919 | 0.81 | ABCC9 (0.61) | KDM4EGAAHSD17B10ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194429-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2005-03-30 | — | — | EP | claimed |
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | claimed |
| EP-1194429-A1 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-10 | — | — | EP | claimed |
| WO-2000078768-A1 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-12-28 | — | — | WO | claimed |
| EP-1194429-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2005-03-30 | — | — | EP | disclosed |
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | disclosed |
| EP-1194429-A1 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078768-A1 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-12-28 | — | — | WO | disclosed |