Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431363 | 0.90 | SRC (0.57) | SRCTGFBR1PDGFRAPDGFRBKDR | |
| SCHEMBL4481865 | 0.78 | SRC (0.60) | SRCTGFBR1PDGFRAPDGFRBKDR | |
| SCHEMBL15338419 | 0.78 | SRC (0.70) | SRCTGFBR1PDGFRAPDGFRBKDR | |
| SCHEMBL3895983 | 0.78 | SRC (0.69) | SRCTGFBR1PDGFRAPDGFRBKDR | |
| SCHEMBL13739661 | 0.78 | SRC (0.60) | SRCTGFBR1PDGFRAPDGFRBKDR | |
| SCHEMBL13787639 | 0.77 | SRC (0.61) | SRCTGFBR1PDGFRAPDGFRBKDR | |
| Hydrochloric Acid SCHEMBL3893940 | 0.76 | SRC (0.67) | SRCTGFBR1PDGFRAPDGFRBKDR | |
| SCHEMBL3894663 | 0.76 | PDGFRB (0.64) | SRCTGFBR1PDGFRAPDGFRBFGFR2 | |
| SCHEMBL5221950 | 0.76 | EGFR (0.55) | SRCTGFBR1PDGFRAPDGFRBKDR | |
| SCHEMBL4400367 | 0.76 | PDGFRB (0.72) | SRCTGFBR1PDGFRAPDGFRBFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |